期刊
CELL REPORTS
卷 28, 期 9, 页码 2317-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2019.07.063
关键词
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类别
资金
- NIH/NCI [U54CA224081, R01CA204302, R01CA211052, R01CA169338, T32CA108462-14]
- Pew Foundation
- Stewart Foundation
- [U54 CA209891]
- [R01GM123159]
- [R01GM118939]
Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor and bi-functional lipid and protein phosphatase. We report that the metabolic regulator pyruvate dehydrogenase kinasel (PDHK1) is a synthetic-essential gene in PTEN-deficient cancer and normal cells. The PTEN protein phosphatase dephosphorylates nuclear factor kappa B (NF-kappa B)-activating protein (NKAP) and limits NF kappa B activation to suppress expression of PDHK1, a NF-kappa B target gene. Loss of the PTEN protein phosphatase upregulates PDHK1 to induce aerobic glycolysis and PDHK1 cellular dependence. PTEN-deficient human tumors harbor increased PDHK1, a biomarker of decreased patient survival. This study uncovers a PTEN-regulated signaling pathway and reveals PDHK1 as a potential target in PTEN-deficient cancers.
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