期刊
CELL AND BIOSCIENCE
卷 9, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13578-019-0330-y
关键词
Epitranscriptomics; N6-methyladenosine (m(6)A); Methyltransferase; Demethylase; Binding protein; Nervous system
资金
- Basic Research Fund of Young Program of Higher Education of Liaoning Province [QNK201735]
- National Natural Science Foundation of China [81302406]
- Funds for Distinguished Young Scientists in School of Public Health, China Medical University
Epitranscriptomics, also known as RNA epigenetics, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (mRNA) methylation modification accounts for more than 60% of all RNA modifications and N6-methyladenosine (m(6)A) is known as one of the most common type of eukaryotic mRNA methylation modifications in current. The m(6)A modification is a dynamic reversible modification, which can directly or indirectly affect biological processes, such as RNA degradation, translation and splicing, and can play important biological roles in vivo. This article introduces the mRNA m(6)A methylation modification enzymes and binding proteins, and reviews the research progress and related mechanisms of the role of mRNA m(6)A methylation in the nervous system from the aspects of neural stem cells, learning and memory, brain development, axon growth and glioblastoma.
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