期刊
STEM CELL RESEARCH & THERAPY
卷 10, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13287-019-1372-0
关键词
Exosomes; Sjogren's syndrome; Corneal allograft rejection; Autoimmune uveitis; Age-related macular degeneration; Biomarkers; Drug delivery
资金
- National Natural Science Foundation of China [81770901, 81570834]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [48]
- Tianjin Clinical Key Discipline Project [TJLCZDXKT003]
Exosomes, nanosized extracellular vesicles of 30-150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora of physiological and pathological processes. Particularly, mounting evidence indicates that immunologically active exosomes can regulate both innate and adaptive immune responses. Herein, we review recent advances in the research of exosomes in several immune-mediated eye diseases, including Sjogren's syndrome (SS) dry eye, corneal allograft rejection, autoimmune uveitis, and age-related macular degeneration (AMD). Additionally, we discuss the potential of exosomes as novel biomarkers and drug delivery vesicles for the diagnosis and treatment of eye diseases.
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