期刊
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
卷 14, 期 11, 页码 1981-1991出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s11548-019-02070-5
关键词
Pancreatic neuroendocrine tumor; Convolutional neural network; Generative adversarial network; Magnetic resonance imaging
Purpose The World Health Organization (WHO) grading system of pancreatic neuroendocrine tumor (PNET) plays an important role in the clinical decision. The rarity of PNET often negatively affects the radiological application of deep learning algorithms due to the low availability of radiological images. We tried to investigate the feasibility of predicting WHO grades of PNET on contrast-enhanced magnetic resonance (MR) images by deep learning algorithms. Materials and methods Ninety-six patients with PNET underwent preoperative contrast-enhanced MR imaging. Fivefold cross-validation was used in which five iterations of training and validation were performed. Within every iteration, on the training set augmented by synthetic images generated from generative adversarial network (GAN), a convolutional neural network (CNN) was trained and its performance was evaluated on the paired internal validation set. Finally, the trained CNNs from cross-validation and their averaged counterpart were separately assessed on another ten patients from a different external validation set. Results Averaging the results across the five iterations in the cross-validation, for the CNN model, the average accuracy was 85.13% +/- 0.44% and micro-average AUC was 0.9117 +/- 0.0053. Evaluated on the external validation set, the average accuracy of the five trained CNNs ranges between 79.08 and 82.35%, and the range of micro-average AUC was between 0.8825 and 0.8932. The average accuracy and micro-average AUC of the averaged CNN were 81.05% and 0.8847, respectively. Conclusion Synthetic images generated from GAN could be used to alleviate the difficulty of radiological image collection for uncommon disease like PNET. With the help of GAN, the CNN showed the potential to predict the WHO grades of PNET on contrast-enhanced MR images.
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