期刊
CURRENT PSYCHIATRY REPORTS
卷 21, 期 10, 页码 -出版社
SPRINGER
DOI: 10.1007/s11920-019-1089-x
关键词
Sex differences; Cognition; Neurocognition; HIV
类别
资金
- National Institute of Mental Health of the National Institutes of Health [R01MH113512, P30MH075773]
Purpose of Review Sex differences in cognitive function are well documented yet few studies had adequate numbers of women and men living with HIV (WLWH; MLWH) to identify sex differences in neurocognitive impairment (NCI) and the factors contributing to NCI. Here, we review evidence that WLWH may be at greater risk for NCI. Recent Findings We conducted a systematic review of recent studies of NCI in WLWH versus MLWH. A power analysis showed that few HIV studies have sufficient power to address male/female differences in NCI but studies with adequate power find evidence of greater NCI in WLWH, particularly in the domains of memory, speed of information processing, and motor function. Sex is an important determinant of NCI in HIV, and may relate to male/female differences in cognitive reserve, comorbidities (mental health and substance use disorders), and biological factors (e.g., inflammation, hormonal, genetic).
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