期刊
BIOMEDICAL OPTICS EXPRESS
卷 10, 期 9, 页码 4825-4838出版社
OPTICAL SOC AMER
DOI: 10.1364/BOE.10.004825
关键词
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资金
- China Scholarship Council
- Natural Sciences and Engineering Research Council of Canada
- Silicon Electronic PhotonicIntegrated Circuits Research Training Program
Sub-wavelength grating (SWG) metamaterials have been considered to provide promising solutions in the development of next-generation photonic integrated circuits. In recent years, increasied interest has been paid to silicon photonic planar biosensors based on SWG geometries for performance enhancement. In this work, we demonstrate a highly sensitive label-free phase-shifted Bragg grating (PSBG) sensing configuration, which consists of sub-wavelength block arrays in both propagation and transverse directions. By introducing salt serial dilutions and electrostatic polymers assays, bulk and surface sensitivities of the proposed sensor are characterized, obtaining measured results up to 579.2 nm/RIU and 1914 pm/nm, respectively. Moreover, the proposed multi-box PSBG sensor presents an improved quality factor as high as similar to 8000, roughly 3-fold of the microring-based counterpart, which further improves the detection limit. At last, by employing a biotin-streptavidin affinity assay, the capability for small molecule monitoring is exemplified with a minimum detectable concentration of biotin down to 2.28 x 10(-8) M. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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