期刊
BIOMEDICAL OPTICS EXPRESS
卷 10, 期 9, 页码 4551-4567出版社
Optica Publishing Group
DOI: 10.1364/BOE.10.004551
关键词
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资金
- National Institutes of Health [EY019312, EY025451, EY027283]
- Research to Prevent Blindness
- Department of Ophthalmology and Visual Sciences at Washington University
- City of Gdynia [3/DOT/2016]
- Fundacja na rzecz Nauki Polskiej [TEAM TECH/2016-3/20]
- Narodowe CentrumNauki [2016/23/B/ST2/00752]
- Horizon 2020 Framework Programme [666295]
- Gavin Herbert Eye Institute
- Department of Ophthalmology, University of California, Irvine
Microperimetry is a subjective ophthalmologic test used to assess retinal function at various specific and focal locations of the visual field. Historically, visible light has been described as ranging from 400 to 720 nm. However, we previously demonstrated that infra-red light can initiate visual transduction in rod photoreceptors by a mechanism of two-photon absorption by visual pigments. Here we introduce a newly designed and constructed two-photon microperimeter. We provide for the first time evidence of the presence of a nonlinear process occurring in the human retina based on psychophysical tests using newly developed instrumentation. Since infra-red light penetrates the aged front of the eye better than visible light, it has the potential for improved functional diagnostics in patients with age-related visual disorders. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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