期刊
BIOMEDICAL OPTICS EXPRESS
卷 10, 期 9, 页码 4775-+出版社
Optica Publishing Group
DOI: 10.1364/BOE.10.004775
关键词
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资金
- Government of the Russian Federation [14.Z50.31.0044]
- Russian Foundation for Basic Research [18-29-08046]
- National Institutes of Health [EB017217]
- National Science Foundation [DBI 1556068, OAI 1457888]
A new type of bimodal contrast agent was made that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell. The increasing of a local ICG concentration that is necessary for the obtaining of self-quenching effect was achieved by freezing-induced loading and layer-by-layer assembly. As a result, an efficient photoacoustic(optoacoustic)/fluorescent contrast agent based on composite indocyanine green/polymer particles was successfully prepared and was characterized by fluorescence and photoacoustic(optoacoustic) tomography in vitro. This type of contrast agent holds good promise for clinical application owing to its high efficiency and biosafety. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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