期刊
ACS COMBINATORIAL SCIENCE
卷 21, 期 10, 页码 705-715出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscombsci.9b00144
关键词
combinatorial chemistry; multicomponent reactions; domino process; carbodiimide; dihydroorotic acid
资金
- Politecnico di Milano
A process featuring a sequential multicomponent reaction followed by a regioselective postcyclization strategy was implemented for the facile synthesis of N,N'-disubstituted dihydroorotic acid amides under mild conditions. We obtained, for the first time, a library of 29 derivatives, encompassing 19 N-u-substituted-N-4-dihydroorotyl-4-aminophenylalanine derivatives, a key residue of gonadotropin-releasing hormone antagonist Degarelix. The corresponding products were prepared from easily accessible starting materials in good to excellent yields with broad substrate scope.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据