4.8 Article

Enantioselective Rhodium-Catalyzed Desymmetric Hydrosilylation of Cyclopropenes

期刊

ACS CATALYSIS
卷 9, 期 10, 页码 9110-9116

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b02623

关键词

homogeneous catalysis; hydrosilylation; cyclopropanes; asymmetric catalysis; rhodium

资金

  1. National Natural Science Foundation of China [NSFC 21702211, 21703051, 21773051]
  2. Zhejiang Provincial Natural Science Foundation of China [LZ18B020001, LY17B030005, LY18B020013]

向作者/读者索取更多资源

Catalytic hydrosilylation of alkenes ranks as one of the most important academic and industrial synthetic reactions in homogeneous catalysis and organosilicon chemistry. In this work, a highly enantioselective Rh-catalyzed desymmetric hydrosilylation reaction of 1,1-disubstituted cyclopropenes with the promotion of chiral DTBM-SEGPHOS is described. It allows for a straightforward access to potentially valuable chiral organosilicon compounds bearing a carbon quaternary stereocenter in high yields with good diastereo- and enantioselectivities (up to >99:1 d.r. and >99% ee) in a 100% atom-efficient manner from readily available starting cyclopropenes and hydrosilanes.

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