期刊
ACS CATALYSIS
卷 9, 期 10, 页码 9253-9258出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b03216
关键词
cyclobutanols; borylation; copper catalysis; cyclization; cyclobutanes
资金
- University of Toronto
- Natural Science and Engineering Research Council (NSERC)
- Alphora/Eurofins
- Kennarshore Inc.
- Walter C. Sumner Memorial Fellowship
- Province of Ontario (OGS)
- Basque Government (Grupos IT908-16)
- UPV/EHU
A diastereo- and enantioselective synthesis of boron-containing cyclobutanols is reported. We exploit an enantioselective borylcupration to generate a chiral benzylic copper intermediate that is intercepted with a proximally tethered ketone. The scaffolds contain an all-carbon quaternary center with a modular boronate moiety which allows access to a variety of synthetically valuable functional groups. This work represents an asymmetric approach to monocyclic cyclobutanols and highlights the utility of copper catalysis in the generation of small-sized rings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据