期刊
ACS CATALYSIS
卷 9, 期 9, 页码 8159-8164出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.9b02830
关键词
photochemistry; copper catalysis; radical carbonylation; aminocarbonylation; oxime esters; amides; nitriles
资金
- NNSFC [21622201, 91856119, 21820102003, 21772053]
- Science and Technology Department of Hubei Province [2017AHB047]
- Fundamental Research Funds for the Central Universities [CCNU19TS051]
- Program of Introducing Talents of Discipline to Universities of China (111 Program) [B17019]
A visible light-induced and exogenous photo-sensitizer-free, copper-catalyzed radical aminocarbonylation of cycloketone oxime esters with CO gas and amines is developed. The mild catalytic system involving CuCl and N,N,N-tridentate ligand shows good reactivity and chemo-selectivity, and tolerates a wide range of cycloketone oxime esters and alkyl/aryl amines, giving the corresponding cyanoalkylated amides in moderate to good yields. Preliminary mechanistic studies suggest that the reaction involves a Cu-I/(CuCuIII)-Cu-II/-based catalytic cycle and radical intermediate.
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