期刊
ONCOLOGY LETTERS
卷 18, 期 5, 页码 5490-5498出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2019.10875
关键词
propyl isothiocyanate; human gastric cancer; apoptosis; reactive oxygen species; mitochondria-dependent pathway
类别
资金
- National Natural Science Foundation of China [81572819]
- Shanghai Key Laboratory of Biliary Tract Disease Research Foundation [17DZ2260200]
Isothiocyanates are a group of compounds that exist in the majority of cruciferous plants. A number of isothiocyanates have been demonstrated to exhibit anticancer effects; however, antitumor properties of propyl isothiocyanate (PITC) have not been evaluated previously. In this study, the possible effects of PITC on gastric cancer (GC) cells were investigated, and the potential underlying mechanisms were explored. The results demonstrated that PITC inhibited cell viability of two GC cell lines and induced cell cycle arrest and apoptosis. Treatment with PITC promoted total glutathione depletion in GC cell lines, leading to reactive oxygen species accumulation and DNA damage, which activated the mitochondria-dependent and p53 signaling pathways to trigger apoptosis in GC cells. The effects of PITC were reversed by N-Acetyl-L-cysteine. The results of the present study revealed the potential mechanisms of PITC on apoptosis induction in GC cells, which may be mediated by mitochondria-dependent apoptosis and DNA damage.
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