期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 480, 期 4, 页码 648-654出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.10.110
关键词
1-(2-Cyclohexylmethoxy-6-hydroxyphenyl)-3-(4-hydroxymethyl-phenyl); propenone (chalcone-21); Hyperpigmentation disorder; Melanin; Melanogenesis; Tyrosinase
资金
- National Research Foundation of Korea - Korea government (MESF) [2014R1A2A1A11053203]
- National Research Foundation of Korea - Korea government (MISP) [2012R1A5A2A44671346]
- Cooperative Research Program of Basic Medical Science and Clinical Science from Seoul National University College of Medicine [800-20160092]
- National Research Foundation of Korea [2014R1A2A1A11053203, 2012R1A5A2A44671346] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Abnormal accumulation of melanin pigments in the skin can be lead to hyperpigmentation disorders and melanoma. Melanin biosynthesis is ultimately regulated by the rate-limiting enzyme tyrosinase. In the present study, we synthesized chalcone derivatives and identified 1-(2-cyclohexylmethoxy-6-hydroxyphenyl)-3-(4-hydroxymethyl-phenyl)-propenone (chalcone-21) as an anti-melanogenic substance in B16F10 melanoma cells. Chalcone-21 strongly inhibited cellular melanin production and tyrosinase activity in B16F10 melanoma cells stimulated with a-melanocyte stimulating hormone (alpha-MSH) or protoporphyrin IX. In addition, the compound suppressed not only the expression of tyrosinase, tyrosinase-related protein-1 (TRP-1), TRP-2, and microphthalmia-associated transcription factor (MITF), but also the transcriptional activity of tyrosinase and MITE Our results demonstrated chalcone-21 to be an effective depigmenting agent. (C) 2016 Elsevier Inc. All rights reserved.
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