期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 476, 期 4, 页码 467-474出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.05.146
关键词
Nasopharyngeal carcinoma (NPC); CD93; Angiogenesis; Proliferation
资金
- Chinese National Natural Science Foundation [81172841, 81202368, 81471603]
- Natural Science Foundation of Jiangsu Province [SBK2015022581]
- Jiangsu Provincial Health Department [Z201005]
- scientific and innovative research project of Nantong [BK2014003, HS2014007, 201HHS]
CD93, also known as the complement component C1q receptor (C1qRp), has been reported to promote the progression of some cancer types. However, the expression and physiological significance of CD93 in nasopharyngeal carcinoma (NPC) remain largely elusive. In this study, we first examined the expression of CD93 in NPC and experimentally manipulated its expression. We observed that vascular CD93 expression is elevated in NPC and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. What's more, we found that CD93 was highly expressed in NPC tissues and cells, and the regulation of CD93 on cell proliferation was determined by cell counting kit (CCK)-8 assay and cell cycle analyses. Our findings provide unique insight into the pathogenesis of NPC and underscore the need to explore novel therapeutic targets such as CD93 to improve NPC treatment. (C) 2016 Elsevier Inc. All rights reserved.
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