期刊
ULTRASOUND IN MEDICINE AND BIOLOGY
卷 45, 期 12, 页码 3128-3136出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2019.08.009
关键词
Microvessel imaging; Ultrafast ultrasound imaging; Tumor angiogenesis; Breast tumor differentiation; Doppler sensitivity
资金
- National Cancer Institute of the National Institutes of Health [R00CA214523]
- National Institute of Diabetes and Digestive and Kidney Diseases [R01DK120559]
Tumor angiogenesis plays an important role during breast tumor growth. However, conventional Doppler has limited sensitivity to detect small blood vessels, resulting in a large overlap of Doppler features between benign and malignant tumors. An ultrasensitive ultrasound microvessel imaging (UMI) technique was recently developed. To evaluate the performance of UMI, we studied 44 patients with 51 breast masses. Tumor pathology served as the gold standard: 28 malignancies and 23 benignities. UMI provided a significant improvement in depicting smaller vessels compared with conventional Doppler. The microvessel morphologies observed on UMI were associated with tumor benign/malignant classification. The diagnostic accuracy of correct Breast Imaging Reporting and Data System (BI-RADS) classification rate (BI-RADS >= 4a: test positive; BI-RADS <= 3: test negative) as a fraction of total mass population was improved by 16% after combining conventional ultrasound with UMI compared with using conventional ultrasound alone. This improvement indicates the potential of UMI in reducing unnecessary benign biopsies and avoiding missed malignant biopsies. (C) 2019 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
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