期刊
TRENDS IN IMMUNOLOGY
卷 40, 期 9, 页码 857-872出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.07.006
关键词
-
类别
资金
- Science Foundation Ireland (SFI) [16/FRL]
- ERC [Stg 679173]
- American Diabetes Association [1-16-JDF-061]
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis. Recently, the immune system has been implicated in the regulation of adipose tissue homeostasis and function. Here, we highlight new insights into the distinct phenotypes and functions of adipose resident leukocytes, including a growing body of work on their role in adipose tissue remodeling and thermogenesis. We discuss how the protective capacity of the adipose immune system can be diminished during obesity, where immune cells promote sterile inflammation leading to insulin resistance. Understanding the role of adipose immune cells across different physiological states and processes is important in understanding the full breadth of adipose immunity and the possibilities to harness immune cells in fat tissue for the treatment of chronic metabolic conditions, including obesity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据