期刊
TRENDS IN IMMUNOLOGY
卷 40, 期 8, 页码 699-718出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.06.004
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资金
- Cancer Research Institute (USA)
- Ovarian Cancer Research Fund Alliance (USA)
- Ovarian Cancer Academy Early-Career Investigator Award of the Department of Defense (USA) [W81XWH-16-1-0438]
- Stand Up to Cancer Innovative Research Grant (USA) [SU2C-AACR-IRG-03-16]
- Pershing Square Sohn Cancer Research Alliance (USA)
Dendritic cells (DCs) are fundamental for the initiation and maintenance of immune responses against malignant cells. Despite the unique potential of DCs to elicit robust anticancer immunity, the tumor microenvironment poses a variety of challenges that hinder competent DC function and consequently inhibit the development of protective immune responses. Here, we discuss recent studies uncovering new molecular pathways and metabolic programs that tumors manipulate in DCs to disturb their homeostasis and evade immune control. We also examine certain state-of-the-art strategies that seek to improve DC function and elicit antitumor responses in hosts with cancer. Understanding and modulating DC metabolism and activity within tumors might help improve the efficacy of T cell-centric immunotherapies.
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