期刊
TRENDS IN IMMUNOLOGY
卷 40, 期 9, 页码 825-841出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2019.07.002
关键词
-
类别
资金
- National Institutes of Health (NIH) [R01 EY019287 06A1, R01 HL138466, R01 HL139714, R21 EY026707 02, K08 HL123519]
- Vision Core Grant [P30 EY02687]
- Glenn Foundation for Medical Research Award
- Starr Foundation
- Kuzma Family Gift Fund
- Jeffrey Fort Innovation Fund
- Vitreoretinal Surgery Foundation
- Burroughs Wellcome Fund [1014782]
- Children's Discovery Institute of Washington University
- St. Louis Children's Hospital [CHII-2015-462, CH-II2017-628]
- Foundation of Barnes-Jewish Hospital [8038-88]
- Research to Prevent Blindness, Inc., New York, NY
- Edward N. and Della L. Thome Foundation Award
- National Eye Institute [5 T32 EY013360]
- Training in Integrative and Systems Biology of Cardiovascular Disease [5 T32 HL13463502]
- NATIONAL EYE INSTITUTE [P30EY002687] Funding Source: NIH RePORTER
Macrophages are important mediators of inflammation and tissue remodeling. Recent insights into the heterogeneity of macrophage subpopulations have renewed interest in their functional diversity in homeostasis and disease. In addition, their plasticity enables them to perform a variety of functions in response to changing tissue contexts, such as those imposed by aging. These qualities make macrophages particularly intriguing cells given their dichotomous role in protecting against, or accelerating, diseases of the cardiovascular system and the eye, two tissues that are particularly susceptible to the effects of aging. We review novel perspectives on macrophage biology, as informed by recent studies detailing the diversity of macrophage identity and function, as well as mechanisms influencing macrophage behavior that might offer opportunities for new therapeutic strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据