期刊
TRENDS IN GENETICS
卷 35, 期 8, 页码 589-600出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2019.05.001
关键词
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资金
- Canadian Institutes of Health Research (CIHR) [152283]
- CIHR [388041, 399687]
- Canada Research Chairs Program (CRC) [950-230661]
- Ontario Graduate Scholarship (OGS)
Genome expression and stability are dependent on biological processes that control repetitive DNA sequences and nuclear compartmentalization. The phase separation of macromolecules has recently emerged as a major player in the control of biological pathways. Here, we summarize recent studies that collectively reveal intersections between phase separation, repetitive DNA elements, and nuclear compartments. These intersections modulate fundamental processes, including gene expression, DNA repair, and cellular lifespan, in the context of health and diseases such as cancer and neurodegeneration.
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