期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 30, 期 12, 页码 944-958出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2019.08.007
关键词
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资金
- National Institutes of Health (NIH) [DK111436, ES027544]
- Children's Nutrition Research Center
- Baylor College of Medicine Cardiovascular Research Institute
- Dan L. Duncan Comprehensive Cancer Center [P30CA125123]
- TexasMedical Center Digestive Diseases Center [P30DK056338]
- SPORE program in lymphoma at Baylor College of Medicine [P50 CA126752]
- Gulf Coast Center for Precision Environmental Health [P30ES030285]
'What doesn't kill you makes you stronger'. Hormesis, the paradoxical beneficial effects of low-dose stressors, can be better defined as the biphasic dose-effect or time-effect relationship for any substance. Here we review hormesis-like phenomena in the chronic diseases for many substances, including lifestyle factors and endocrine factors. Intermitent or pulsatile exposure can generate opposite effects compared with continuous exposure. An initial exposure can elicit an adaptive stress response with long-lasting protection against subsequent exposures. Early-life stress can increase resilience in later life and lack of stress can lead to vulnerability. Many stressors are naturally occurring and are required for healthy growth or homeostasis, which exemplifies how 'illness is the doorway to health'.
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