Coinage metal catalyzed 7-endo-trig cyclization of ene-diols: Construction of 2,2-dimethyloxepane frameworks

The silver catalyzed 7-endo-trig cyclization of an ene-diol for the formation of 2,2-dimethyloxepane frameworks has been developed. The spirotype dioxabicyclic products were also produced from the diene-diols. In addition, a gold catalyst featuring the Z-ligand also produced similar cyclization reactions. (C) 2019 Published by Elsevier Ltd.