期刊
TETRAHEDRON
卷 75, 期 36, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2019.130493
关键词
Retention of chirality; 5-Membered alicyclic alpha-amino acid; Photoinduced decarboxylation; Photoinduced decarboxylative intermolecular radical addition; Memory of chirality
资金
- Japan Society for the Promotion of Science (JSPS) [17K05779]
- Grants-in-Aid for Scientific Research [17K05779] Funding Source: KAKEN
Photoinduced decarboxylative radical additions of 5-membered alicyclic alpha-amino acids bearing a (2-phenyl)benzoyl protective group to acrylonitrile under mild organic photoredox catalysis conditions furnished gamma-amino acid derivatives with high retention of chirality via the memory of chirality (MOC) strategy. The retention of chirality in the photoinduced decarboxylation was strongly dependent on the structure of the alicyclic alpha-amino acids and alkenes. To the best of our knowledge, this is the first example of the decarboxylative intermolecular radical addition to alkenes with retention of chirality at the position of radical generation using the MOC strategy. (C) 2019 Elsevier Ltd. All rights reserved.
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