期刊
TALANTA
卷 201, 期 -, 页码 350-357出版社
ELSEVIER
DOI: 10.1016/j.talanta.2019.04.037
关键词
Bisphenol A; DNA damage; Biosensor
资金
- research council of Kermanshah University of medical Science
In this work, a novel electrochemical biosensor has been fabricated based on step-by-step modification of a glassy carbon electrode (GCE) with methylene blue (MB)-DNA/multiwalled carbon nanotubes (MWCNTs)-chitosan (CS)/palladium nanoparticles (Pd NPs)/fullerene C-60 (C-60) for voltammetric and impedimetric detection of DNA damage induced by bisphenol A (BPA). Modifications applied to the GCE were characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy. The EIS and DPV responses of the biosensor were increased and decreased, respectively, by the DNA damage induced by BPA which led us to develop novel systems for detection of DNA damage. Our records confirmed that the biosensor was able to rapid and sensitive detection of DNA damage induced by BPA. Finally, according to the developed systems for detection of DNA damage, we have developed voltammetric and impedimetric methods for determination of BPA.
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