期刊
SYNTHESIS-STUTTGART
卷 51, 期 20, 页码 3784-3791出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0037-1611907
关键词
site-selective; diol; acylation; aqueous; acyl phosphate monoesters; metal ions; chelation
资金
- Natural Sciences and Engineering Research Council of Canada [A9918]
Site-selective reactions of water-soluble biomolecules are being developed to produce efficient conversions in water and water-/solvent mixtures. This review focuses on the use of designs based on bis-bidentate chelation of large metal ions by diols to be acylated by a co-chelated water-stable reagent. Topics discussed include: 1. The preparation and properties of water-stable acyl phosphate monoesters and their reactions with diol-chelated metal ions. 2. Site-selective monoaminoacylation of 3 '-terminal diols of RNA and their applications in protein engineering. 3. Site-selective monoacylation of sugars with acyl phosphate monoesters associated with metal ions, including lanthanum and lead. The combination of metal ion, 1,2-diol, and acyl phosphate monoester produces site-selective reactions in aqueous media- that can produce a general approach to site-selective mono-(amino)acylation in RNA and carbohydrates. 1 Introduction 2 Synthetic Aminoacylation of tRNA 3 Activated Amino Acids in Water 4 Metal Ions and Their Effects on the Reactivity of Acyl Phosphate Monoesters 5 The Challenge of Site-Selective Acylation of Carbohydrates in Water 6 Conclusions and Prospects
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