期刊
SYNTHESIS-STUTTGART
卷 51, 期 22, 页码 4249-4252出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0039-1690617
关键词
penoxsulam; regioselective lithiation; benzyne intermediate; C-O coupling; chloroxidation
资金
- Natural Science Foundation of Zhejiang Province [LY17E030003]
- Hangzhou Science and Technology Bureau of China [20160432B08, 20170533B08]
A convenient and efficient three-step synthesis of 2-(2,2-difluoroethoxy)-6-(trifluoromethyl)benzenesulfonyl chloride, the key building block of penoxsulam, is described. The main features of the synthesis include a regioselective lithiation and subsequent electrophilic substitution starting from commercially available 3-bromobenzotrifluoride to provide (2-bromo-6-(trifluoromethyl)phenyl)(propyl)sulfane, then a copper-catalyzed C-O coupling to introduce the difluoroethoxy moiety and chloroxidation conditions to give the desired sulfonyl chloride.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据