期刊
STEROIDS
卷 149, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.steroids.2019.108425
关键词
Soft coral; Sinularia sp.; Ergostane; Antiproliferative activity; Apoptosis
资金
- Drug Innovation Major Project [2018ZX09711-001-001-009]
- State Key Basic Research Program of the PRC [2018YFC0310903]
- NSFC-Shandong Joint Fund for Marine Science Research Center [U1606403]
- Natural Science Foundation of China [81520108028, 21672230]
- SKLDR/SIMM Project [SIMM1903ZZ-04]
Two new highly oxygenated ergostane-type sterols (1, 2) together with one known related compound sinugrandisterol A (3) were isolated from the soft coral Sinularia sp. collected from the water area near the Xisha Islands, South China Sea. Their structures were elucidated on the basis of detailed spectroscopic analysis, chemical transformations, and by comparison with those reported in literature. In bioassays, compounds 1 and 2 showed in vitro antiproliferative activity against a panel of cancer cell lines, including MDA-MB-436, A549, Hep3B, HT-29 and H157. Morphological observation and Hoechst 33,258 staining assays showed that compound 1-treated H157 cells displayed apoptosis characteristics. Moreover, western blot assays suggested that 1 could increase the expression of Bax and down-regulate expression of Bcl-2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据