期刊
STEM CELLS AND DEVELOPMENT
卷 28, 期 22, 页码 1514-1526出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2019.0158
关键词
stem cells; exfoliated deciduous teeth; conditioned medium; stem cell therapy; retinal degeneration; retinitis pigmentosa
资金
- National Natural Science Foundation of China [303076129, 81772873, 81970920]
- Beijing Natural Science Foundation [7172240, 7182181]
- Stomatology Development Fund of Tason
Retinitis pigmentosa (RP) is a hereditary disease characterized by degeneration and the loss of photoreceptors. Stem cell-based therapy has emerged as a promising strategy for treating RP. Stem cells from exfoliated deciduous teeth (SHEDs), a type of mesenchymal stem cell from human exfoliated deciduous teeth, have the potential to differentiate into photoreceptor-like cells under specific induction in vitro. It has been confirmed that through paracrine secreta, SHEDs exert neurotrophic, angiogenic, immunoregulatory, and antiapoptotic functions in injured tissues. This study was designed to determine whether retinal-differentiated SHEDs and the conditioned medium derived from SHEDs (SHEDs-CM) have therapeutic effects in a mouse model of RP. The results showed that both SHEDs and SHEDs-CM improved electroretinogram responses, ameliorated photoreceptor degeneration, and maintained the structure of the outer segments of photoreceptors. The therapeutic effects were related to antiapoptotic activity of SHEDs and SHEDs-CM. Thus, SHEDs may be a promising stem cell source for treating retinal degeneration.
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