Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydro-isoquinoline mediated by a visible light photoredox catalyst

This report describes a highly enantioselective oxidative sp(3) C-H arylation of N-aryltetrahydroisoquinolines ( THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir( ppy)(2)(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp(3) C-H asymmetric arylation of THIQs.