期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 12, 期 -, 页码 2614-2619出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.12.257
关键词
chemoselectivity; continuous processes; flow synthesis; nitro reduction; trichlorosilane
资金
- University of Milan
The metal-free reduction of nitro compounds to amines mediated by trichlorosilane was successfully performed for the first time under continuous-flow conditions. Aromatic as well as aliphatic nitro derivatives were converted to the corresponding primary amines in high yields and very short reaction times with no need for purification. The methodology was also extended to the synthesis of two synthetically relevant intermediates (precursors of baclofen and boscalid).
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