期刊
SMALL
卷 15, 期 42, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201903087
关键词
biomolecules; controlled release; inhomogeneous microcapsules; microfluidics; osmotic pressure
类别
资金
- National Science Foundation [DMR-1708729]
- Harvard Materials Research Science and Engineering Center [DMR-1420570]
- Wyss Institute for Biologically Inspired Engineering at Harvard University
Inhomogeneous microcapsules that can encapsulate various cargo for controlled release triggered by osmotic shock are designed and reported. The microcapsules are fabricated using a microfluidic approach and the inhomogeneity of shell thickness in the microcapsules can be controlled by tuning the flow rate ratio of the middle phase to the inner phase. This study demonstrates the swelling of these inhomogeneous microcapsules begins at the thinnest part of shell and eventually leads to rupture at the weak spot with a low osmotic pressure. Systematic studies indicate the rupture fraction of these microcapsules increases with increasing inhomogeneity, while the rupture osmotic pressure decreases linearly with increasing inhomogeneity. The inhomogeneous microcapsules are demonstrated to be impermeable to small probe molecules, which enables long-term storage. Thus, these microcapsules can be used for long-term storage of enzymes, which can be controllably released through osmotic shock without impairing their biological activity. The study provides a new approach to design effective carriers to encapsulate biomolecules and release them on-demand upon applying osmotic shock.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据