期刊
SLEEP
卷 43, 期 2, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsz218
关键词
arousal; sleep; fMRI; EEG; activation; deactivation
资金
- National Key Research and Development Program of China [2018YFC2000603, 2017YFC0108900]
- China's National Strategic Basic Research Program (973) grant [2015CB856400]
- National Natural Science Foundation of China [81871427, 81671765, 81430037, 81727808, 81790650, 81790651, 31421003]
- Beijing Municipal Natural Science Foundation [7172121]
- Beijing Municipal Science & Technology Commission [Z181100001518005, Z161100002616006, Z171100000117012]
- Shenzhen Peacock Plan [KQTD2015033016104926]
- Guangdong Pearl River Talents Plan Innovative and Entrepreneurial Team [2016ZT06S220]
- Shenzhen Science and Technology Research Funding Program [JCYJ20170412164413575]
Arousals commonly occur during human sleep and have been associated with several sleep disorders. Arousals are characterized as an abrupt electroencephalography (EEG) frequency change to higher frequencies during sleep. However, the human brain regions involved in arousal are not yet clear. Simultaneous EEG and functional magnetic resonance imaging (fMRI) data were recorded during the early portion of the sleep period in healthy young adults. Arousals were identified based on the EEG data, and fMRI signal changes associated with 83 arousals from 19 subjects were analyzed. Subcortical regions, including the midbrain, thalamus, basal ganglia, and cerebellum, were activated with arousal. Cortices, including the temporal gyrus, occipital gyrus, and frontal gyrus, were deactivated with arousal. The activations associated with arousal in the subcortical regions were consistent with previous findings of subcortical involvement in behavioral arousal and consciousness. Cortical deactivations may serve as a mechanism to direct incoming sensory stimuli to specific brain regions, thereby monitoring environmental perturbations during sleep.
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