4.5 Review

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

期刊

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 12, 期 -, 页码 1512-1550

出版社

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.12.148

关键词

biosynthesis; chemoenzymatic synthesis; enzymology; heterocycles; polyketides

资金

  1. Deutsche Forschungsgemeinschaft
  2. European Union for a Career Integration Grant

向作者/读者索取更多资源

This review highlights the biosynthesis of heterocycles in polyketide natural products with a focus on oxygen and nitrogen-containing heterocycles with ring sizes between 3 and 6 atoms. Heterocycles are abundant structural elements of natural products from all classes and they often contribute significantly to their biological activity. Progress in recent years has led to a much better understanding of their biosynthesis. In this context, plenty of novel enzymology has been discovered, suggesting that these pathways are an attractive target for future studies.

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