期刊
SEMINARS IN CANCER BIOLOGY
卷 60, 期 -, 页码 148-156出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.09.007
关键词
Dormancy; Stem cell niche; Angiogenesis; EMT; Migration; Invasion
类别
资金
- Austrian Science Fund (FWF) [P29457, I4140]
- Anniversary Fund of Austrian National Bank [ONB 17620]
- Ingrid Shaker-Nessmann Cancer Research Foundation
- Austrian Science Fund (FWF) [P29457] Funding Source: Austrian Science Fund (FWF)
Cancer stem cells (CSC) possess abilities generally associated with embryonic or adult stem cells, especially self-renewal and differentiation, but also dormancy and cellular plasticity that allow adaption to new environmental circumstances. These abilities are ideal prerequisites for the successful establishment of metastasis. This review highlights the role of CSCs in every step of the metastatic cascade from cancer cell invasion into blood vessels, survival in the blood stream, attachment and extravasation as well as colonization of the host organ and subsequent establishment of distant macrometastasis.
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