4.6 Article

Implications of nanotechnology for the treatment of cancer: Recent advances

期刊

SEMINARS IN CANCER BIOLOGY
卷 69, 期 -, 页码 190-199

出版社

ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2019.08.028

关键词

Nano-drugs; Nano-technology; Cancer; Drug delivery; Oncotarget

类别

资金

  1. Ministry of Science and High Education of the Russian Federation [14.613.21.0086, RFMEFI61318 x 0086]
  2. Russian Academic Excellence project 5-100''

向作者/读者索取更多资源

The use of nanoparticles in anticancer drugs improves safety and efficacy, with advantages such as effective targeting, delayed release, increased half-life, and reduced systemic toxicity. Nano-carriers have shown significant improvements in drug delivery compared to traditional administration, but there are still limitations in their clinical use.
The use of nanoparticles dramatically increases the safety and efficacy of the most common anticancer drugs. The main advantages of nano-drugs and delivery systems based on nano-technology are effective targeting, delayed release, increased half-life, and less systemic toxicity. The use of nano-carriers has led to significant improvements in drug delivery to targets compared with traditional administration of these drugs. In this review, the main tendencies in nano-drug formulations as well as factors limiting their use in clinical settings are discussed. Additionally, the current status of approved nano-drugs for cancer treatment is reviewed.

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