相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A Landscape of Metabolic Variation across Tumor Types
Ed Reznik et al.
CELL SYSTEMS (2018)
Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma
Sara A. Byron et al.
CLINICAL CANCER RESEARCH (2018)
Purine synthesis promotes maintenance of brain tumor initiating cells in glioma
Xiuxing Wang et al.
NATURE NEUROSCIENCE (2017)
BIOMEDICAL INNOVATION How economics can shape precision medicines Innovation incentives, pricing, and access are critical
A. D. Stern et al.
SCIENCE (2017)
Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis
Maria Moreno-Morcillo et al.
STRUCTURE (2017)
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition
Deepti Mathur et al.
CANCER DISCOVERY (2017)
Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer
Kristin K. Brown et al.
CANCER DISCOVERY (2017)
Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma
Erika Cosset et al.
CANCER CELL (2017)
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
Alexander J. Valvezan et al.
CANCER CELL (2017)
MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells
Xiuxing Wang et al.
CANCER RESEARCH (2017)
Targeting Metabolism for Cancer Therapy
Alba Luengo et al.
CELL CHEMICAL BIOLOGY (2017)
Nicotinamide metabolism regulates glioblastoma stem cell maintenance
Jinkyu Jung et al.
JCI INSIGHT (2017)
American Brain Tumor Association Adolescent and Young Adult Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012
Quinn T. Ostrom et al.
NEURO-ONCOLOGY (2016)
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia
David B. Sykes et al.
CELL (2016)
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
Michele Ceccarelli et al.
CELL (2016)
Analysis of protein-coding genetic variation in 60,706 humans
Monkol Lek et al.
NATURE (2016)
Fundamentals of cancer metabolism
Ralph J. DeBerardinis et al.
SCIENCE ADVANCES (2016)
A global reference for human genetic variation
David M. Altshuler et al.
NATURE (2015)
Toward precision medicine in glioblastoma: the promise and the challenges
Michael D. Prados et al.
NEURO-ONCOLOGY (2015)
Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors
Jeanette E. Eckel-Passow et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Regulation of mammalian nucleotide metabolism and biosynthesis
Andrew N. Lane et al.
NUCLEIC ACIDS RESEARCH (2015)
CopywriteR: DNA copy number detection from off-target sequence data
Thomas Kuilman et al.
GENOME BIOLOGY (2015)
Targeting Metabolic Changes in Cancer: Novel Therapeutic Approaches
Ekaterina Bobrovnikova-Marjon et al.
ANNUAL REVIEW OF MEDICINE, VOL 65 (2014)
Epidermal Growth Factor Receptor ( EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma
Hideki Makinoshima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Anoop P. Patel et al.
SCIENCE (2014)
Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells
Annegret Kathagen et al.
ACTA NEUROPATHOLOGICA (2013)
Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth
Lin Cheng et al.
CELL (2013)
The Somatic Genomic Landscape of Glioblastoma
Cameron W. Brennan et al.
CELL (2013)
A Phase I/II Trial of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma
David A. Reardon et al.
CLINICAL CANCER RESEARCH (2013)
Genomics-Driven Oncology: Framework for an Emerging Paradigm
Levi A. Garraway
JOURNAL OF CLINICAL ONCOLOGY (2013)
Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
William A. Flavahan et al.
NATURE NEUROSCIENCE (2013)
Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
Ping Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra et al.
SCIENCE (2013)
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Aaron M. Robitaille et al.
SCIENCE (2013)
An update of teriflunomide for treatment of multiple sclerosis
Jiwon Oh et al.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT (2013)
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Patrick S. Ward et al.
CANCER CELL (2012)
IDH mutation impairs histone demethylation and results in a block to cell differentiation
Chao Lu et al.
NATURE (2012)
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
Sevin Turcan et al.
NATURE (2012)
NIH Image to ImageJ: 25 years of image analysis
Caroline A. Schneider et al.
NATURE METHODS (2012)
Current clinical development of PI3K pathway inhibitors in glioblastoma
Patrick Y. Wen et al.
NEURO-ONCOLOGY (2012)
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas
Yuchen Jiao et al.
ONCOTARGET (2012)
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
Sophia Y. Lunt et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)
GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition
Aidan G. Gilmartin et al.
CLINICAL CANCER RESEARCH (2011)
PHASE II EVALUATION OF GEFITINIB IN PATIENTS WITH NEWLY DIAGNOSED GRADE 4 ASTROCYTOMA: MAYO/NORTH CENTRAL CANCER TREATMENT GROUP STUDY N0074
Joon H. Uhm et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)
DHODH modulates transcriptional elongation in the neural crest and melanoma
Richard Mark White et al.
NATURE (2011)
Randomized Trial of Oral Teriflunomide for Relapsing Multiple Sclerosis
Paul O'Connor et al.
NEW ENGLAND JOURNAL OF MEDICINE (2011)
Metabolic state of glioma stem cells and nontumorigenic cells
Erina Vlashi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer
Matthew T. Burger et al.
ACS MEDICINAL CHEMISTRY LETTERS (2011)
Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
Roel G. W. Verhaak et al.
CANCER CELL (2010)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
Zhizhong Li et al.
CANCER CELL (2009)
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Lonneke A. M. Gravendeel et al.
CANCER RESEARCH (2009)
Rembrandt: Helping Personalized Medicine Become a Reality through Integrative Translational Research
Subha Madhavan et al.
MOLECULAR CANCER RESEARCH (2009)
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
Roger Stupp et al.
LANCET ONCOLOGY (2009)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Analysis of gene expression and chemoresistance of CDI33+ cancer stem cells in glioblastoma
Gentao Liu et al.
MOLECULAR CANCER (2006)
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
Shideng Bao et al.
CANCER RESEARCH (2006)
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
HS Phillips et al.
CANCER CELL (2006)
Gene expression profiling of gliomas strongly predicts survival
WA Freije et al.
CANCER RESEARCH (2004)
Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway
DR Evans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Regulation of carbamoyl phosphate synthetase by MAP kinase
LM Graves et al.
NATURE (2000)