Skin inflammation induced by ambient particulate matter in China

Most published studies on particulate matter (PM) concerning PM2.5 and PM10 have focused on PM-induced effects on the respiratory system (particularly lung) and cardiovascular system effects. However, epidemiological and mechanistic studies suggest that PM2.5 and PM10 also affects the skin, which is a key health issue. In this study, we first reviewed the current status of PM2.5 and PK10 in China, including relevant regulations, concentration levels, chemical components, and emission sources. Next, we summarized the association between PM2.5 and PM10 or its representative components, in relation to skin inflammation as well as inflammatory skin diseases, such as atopic dermatitis, acne, eczema, and skin aging. Finally, we determined the mechanism of oxidative stress or programmed cell death induced through PM, which can provide useful information for future research on PM-induced skin inflammation. (C) 2019 Elsevier B.V. All rights reserved.