期刊
SCIENCE CHINA-CHEMISTRY
卷 62, 期 11, 页码 1529-1536出版社
SCIENCE PRESS
DOI: 10.1007/s11426-019-9528-2
关键词
asymmetric radical chemistry; aminosilylation; alkenes; Cu; chiral phosphoric acid; silyl radical
The catalytic radical-initiated asymmetric 1,2-aminosilylation of alkene with a hydrosilane under Cu(I)/CPA cooperative catalysis has been developed. This method features the use of hydrosilane as the reductive radical precursor, enabling efficient access to skeletally diverse silicon-containing azaheterocycles including pyrrolidine, indoline and isoindoline bearing an alpha-tertiary stereocenter with high enantioselectivity. The key to the success includes the use of Cu(I)/CPA cooperative catalyst system and the beta-silicon effect of the silyl group to stabilize the in situ generated carbocation intermediate.
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