期刊
SCIENCE
卷 365, 期 6460, 页码 1466-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aav7321
关键词
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资金
- NNF [NNF15OC0016662]
- ERC [724718-ReCAP]
- DNRF [DNRF115]
- Carlsberg Foundation [CF15-0232]
- DFF-FSS [6110-00344B]
- MRC [MR/M000664/1]
- University of Warwick
- University Hospitals Coventry
- Warwickshire NHS Trust
- Max Planck Society
- European Research Council [337415]
- Lister Institute for Preventive Medicine
- Rosetrees Trust
- European Research Council (ERC) [337415] Funding Source: European Research Council (ERC)
- MRC [MR/M000664/1] Funding Source: UKRI
Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions. causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.
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