期刊
SCIENCE
卷 365, 期 6456, 页码 910-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax3353
关键词
-
资金
- EPSRC [EP/R030693/1, EP/L015633/1]
- Leverhulme Trust [RPG-2014-190]
- Syngenta
- GlaxoSmithKline
- School of Chemistry, University of Nottingham
- EPSRC [EP/S035990/1, EP/R030693/1] Funding Source: UKRI
Nucleophilic substitution reactions of alcohols are among the most fundamental and strategically important transformations in organic chemistry. For over half a century, these reactions have been achieved by using stoichiometric, and often hazardous, reagents to activate the otherwise unreactive alcohols. Here, we demonstrate that a specially designed phosphine oxide promotes nucleophilic substitution reactions of primary and secondary alcohols in a redox-neutral catalysis manifold that produces water as the sole by-product. The scope of the catalytic coupling process encompasses a range of acidic pronucleophiles that allow stereospecific construction of carbon-oxygen and carbon-nitrogen bonds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据