期刊
SCIENCE
卷 365, 期 6459, 页码 1265-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax1971
关键词
-
资金
- NIH [U41HG007355, R01GM072675, R35GM127093, R21HD085201]
- Commonwealth of Pennsylvania Health Research Formula Funds
- William H. Gates Chair of Biomedical Sciences
- Allen Discovery Center for Lineage Tracing
- [RM1HG010023]
- [U2C CA233285]
Caenorhabditis elegans is an animal with few cells but a wide diversity of cell types. In this study, we characterize the molecular basis for their specification by profiling the transcriptomes of 86,024 single embryonic cells. We identify 502 terminal and preterminal cell types, mapping most single-cell transcriptomes to their exact position in C. elegans' invariant lineage. Using these annotations, we find that (i) the correlation between a cell's lineage and its transcriptome increases from middle to late gastrulation, then falls substantially as cells in the nervous system and pharynx adopt their terminal fates; (ii) multilineage priming contributes to the differentiation of sister cells at dozens of lineage branches; and (iii) most distinct lineages that produce the same anatomical cell type converge to a homogenous transcriptomic state.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据