期刊
SCIENCE
卷 365, 期 6456, 页码 882-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat7693
关键词
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资金
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [R01HD041563, R21HD080410, P01-HD031921]
- Australian Research Council [FT160100298]
- Knut and Alice Wallenberg Foundation [2015.0327]
- Swedish Research Council [2016-00250]
- National Institutes of Health (NIH) [1R01MH107649-03]
- National Science Foundation's Graduate Research Fellowship Program [DGE 1144083]
- ZonMw grants from the Netherlands Organisation for Health Research and Development [849200011, 531003014]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) [R01 HD073342, R01 HD060726]
- Swedish Council for Working Life and Social Research [2014-0834]
- MRC [MC_UU_12015/2] Funding Source: UKRI
- Swedish Research Council [2016-00250] Funding Source: Swedish Research Council
- Australian Research Council [FT160100298] Funding Source: Australian Research Council
- Forte [2016-00250] Funding Source: Forte
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
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