期刊
RNA BIOLOGY
卷 17, 期 11, 页码 1674-1679出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15476286.2019.1657744
关键词
tRNA; codon; amino acid; cancer; codon usage
资金
- Cancer Prevention & Research Institute of Texas [RR150085]
- UTHealth Innovation for Cancer Prevention Research Training Program Post-doctoral Fellowship (Cancer Prevention and Research Institute of Texas) [RP160015]
- China Postdoctoral Science Foundation [2019M652623]
- National Natural Science Foundation of China [31822030, 31771458]
Transfer RNAs (tRNAs) play critical roles in human cancer. Currently, no database provides the expression landscape and clinical relevance of tRNAs across a variety of human cancers. Utilizing miRNA-seq data from The Cancer Genome Atlas, we quantified the relative expression of tRNA genes and merged them into the codon level and amino level across 31 cancer types. The expression of tRNAs is associated with clinical features of patient smoking history and overall survival, and disease stage, subtype, and grade. We further analysed codon frequency and amino acid frequency for each protein coding gene and linked alterations of tRNA expression with protein translational efficiency. We include these data resources in a user-friendly data portal, tRic (tRNA in cancer, or ), which can be of significant interest to the research community.
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