期刊
BEHAVIOURAL BRAIN RESEARCH
卷 314, 期 -, 页码 16-20出版社
ELSEVIER
DOI: 10.1016/j.bbr.2016.07.034
关键词
Animal models; Anxiety; Fear; Behavioral defense
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Both the lateral septum (LS) and anterior hypothalamus (AHA) regulate behavioural defense. We tested whether those two interconnected structures act in serial in that regard. Infusions of the GABA(A) agonist muscimol into one side of the LS and the contralateral (but not ipsilateral) AHA suppressed rats' burying in the shock-probe test whereas none of our muscimol infusion approaches altered their open-arm avoidance in the elevated plus-maze. These results suggest that the LS-AHA circuit serves a specialized role in defensive responses towards discrete, localizable threat stimuli but not towards potential threats. (C) 2016 Elsevier B.V. All rights reserved.
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