期刊
BEHAVIOURAL BRAIN RESEARCH
卷 302, 期 -, 页码 263-268出版社
ELSEVIER
DOI: 10.1016/j.bbr.2016.01.035
关键词
Mouse; Hippocampus; Spine density; Exploratory behavior; Irradiation
资金
- NASA [NNX08BA07G, NNX13AD60G, NNJ12ZSA001N]
- NASA [NNX08BA07G, 474979, NNX13AD60G, 91690] Funding Source: Federal RePORTER
A unique feature of the space radiation environment is the presence of high-energy charged particles, including Fe-56 ions, which can present a significant hazard to space flight crews during and following a mission. Fe-56 irradiation-induced cognitive changes often involve alterations in hippocampal function. These alterations might involve changes in spine morphology and density. In addition to irradiation, performing a cognitive task can also affect spine morphology. Therefore, it is often hard to determine whether changes in spine morphology and density are due to an environmental challenge or group differences in performance on cognitive tests. In this study, we tested the hypothesis that the ability of exploratory behavior to increase specific measures of hippocampal spine morphology and density is affected by Fe-56 irradiation. In sham-irradiated mice, exploratory behavior increased basal spine density in the CA1 region of the hippocampus and the enclosed blade of the dentate gyrus. These effects were not seen in irradiated mice. In addition, following exploratory behavior, there was a trend toward a decrease in the percent stubby spines on apical dendrites in the CA3 region of the hippocampus in Fe-56-irradiated, but not sham-irradiated, mice. Other hippocampal regions and spine measures affected by Fe-56 irradiation showed comparable radiation effects in behaviorally naive and cognitively tested mice. Thus, the ability of exploratory behavior to alter spine density and morphology in specific hippocampal regions is affected by Fe-56 irradiation. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据