期刊
RESEARCH IN MICROBIOLOGY
卷 170, 期 8, 页码 435-447出版社
ELSEVIER
DOI: 10.1016/j.resmic.2019.09.005
关键词
ABC superfamily; ABC-F protein family; mRNA translation; Translation regulation; Antibiotic resistance; ATPase
类别
资金
- LABEX program [DYNAMO ANR-11-LABX-0011]
- French Agence Nationale de la Recherche grant EZOtrad [ANR-14-ACHN-0027]
- US National Institutes of Health [1R01GM120579]
- French Agence Nationale de la Recherche grant ABC-F_AB [ANR-18-CE35-0010]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE35-0010, ANR-14-ACHN-0027] Funding Source: Agence Nationale de la Recherche (ANR)
The ATP binding cassette protein superfamily comprises ATPase enzymes which are, for the most part, involved in transmembrane transport. Within this superfamily however, some protein families have other functions unrelated to transport. One example is the ABC-F family, which comprises an extremely diverse set of cytoplasmic proteins. All of the proteins in the ABC-F family characterized to date act on the ribosome and are translation factors. Their common function is ATP-dependent modulation of the stereochemistry of the peptidyl transferase center (PTC) in the ribosome coupled to changes in its global conformation and P-site tRNA binding geometry. In this review, we give an overview of the function, structure, and theories for the mechanisms-of-action of microbial proteins in the ABC-F family, including those involved in mediating resistance to ribosome-binding antibiotics. (C) 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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