期刊
PUBLIC HEALTH
卷 174, 期 -, 页码 42-48出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.puhe.2019.05.032
关键词
Hand, foot, and mouth disease; Transmissibility; Reproduction number; Mathematical model
资金
- Open Research Fund of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics [SKLVD2018KF001, SKLVD2018KF002]
Objective: Hand, foot, and mouth disease (HFMD) is a serious public health issue in many countries; however, its transmissibility in county-level outbreaks remains unclear. The aim of this study is to estimate the transmissibility of HFMD epidemics on both city level and county level, for a better understanding of the transmission dynamics of HFMD epidemics. Study design: Simulation based on data obtained from the China Information System for Disease Control and Prevention. Methods: The weekly number of reported HFMD cases from April 2009 to December 2017 in nine regions of Changsha City was collected. A susceptible-infectious-recovered model was used to estimate the transmissibility of HFMD. The reproduction number of reported cases during the ascending (denoted as R-ase) and descending (denoted as R-des) period was used to describe the transmissibility of HFMD. Results: The R-asc and R-des for HFMD in Changsha was 1.44 (95% confidence interval [CI]: 1.41 -1.48) and 0.71 (95% CI: 0.69-0.73), respectively. There was no statistical significance of R-asc values among nine regions (F = 1.056, P = 0.396), nor of R-des values among nine regions (F = 1.676, P = 0.106). The average R-asc (1.53, 95% CI: 1.46-1.61) from 2009 to 2012 was higher than the one (1.37, 95% CI: 1.34-1.40) from 2013 to 2017 (t = 3.974, P < 0.001), but the average R-des (0.67, 95% CI: 0.63-0.70) from 2009 to 2012 was lower than the one (0.74, 95% CI: 0.73 -0.76) from 2013 to 2017 (t = -3.751, P < 0.001). Conclusions: The epidemic of HFMD in Changsha City is still grim, and integrated strategies should be taken for controlling and preventing HFMD. (C) 2019 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
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