期刊
PROTEIN ENGINEERING DESIGN & SELECTION
卷 32, 期 2, 页码 103-108出版社
OXFORD UNIV PRESS
DOI: 10.1093/protein/gzz018
关键词
kinetic trapping; kinetics; metastability; protein folding; thermodynamics
资金
- National Science Foundation [MCB-1616459]
The founding principles of protein folding introduced by Christian Anfinsen, together with the numerous mechanistic investigations that followed, assume that protein folding is a thermodynamically controlled process. On the other hand, this review underscores the fact that thermodynamic control is far from being the norm in protein folding, as long as one considers an extended chemical-potential landscape encompassing aggregates, in addition to native, unfolded and intermediate states. Here, we highlight the key role of kinetic trapping of the protein native state relative to unfolded, intermediate and, most importantly, aggregated states. We propose that kinetic trapping serves an important role in biology by protecting the bioactive states of a large number of proteins from deleterious aggregation. In the event that undesired aggregates were somehow formed, specialized intracellular disaggregation machines have evolved to convert any aberrant populations back to the native state, thus restoring a fully bioactive and aggregation-protected protein cohort.
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