期刊
PROGRESS IN RETINAL AND EYE RESEARCH
卷 75, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.preteyeres.2019.100779
关键词
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资金
- Research to Prevent Blindness
- Shulsky Foundation
- Hartwell Foundation
- Foundation Fighting Blindness
- National Institutes of Health [UG1EY026876-01A1, P30EY014801, P30EY001319, R01EY022631]
- Department of Defense [W81XWH-09-1-0675]
- Klorfine Foundation
- BrightFocus Foundation
- Gates Family Foundation
- Doni Solich Family Foundation
- California Institute for Regenerative Medicine
- Polly and Michael Smith Foundation
- Medical Research Council
- NIHR
- Oxstem Ocular
- Royal College of Surgeons of Edinburgh
- Center for Biosystems Dynamics Research, RIKEN
- Price Foundation
- UCLA Broad Stem Cell Research Center
- Stein Eye Institute Clinical Research Center, UCLA Department of Ophthalmology
- National Eye Institute Intramural Research Program
- Common Funds Therapeutic Challenge Award
Stem cell transplantation holds great promise as a potential treatment for currently incurable retinal degenerative diseases that cause poor vision and blindness. Recently, safety data have emerged from several Phase I/II clinical trials of retinal stem cell transplantation. These clinical trials, usually run in partnership with academic institutions, are based on sound preclinical studies and are focused on patient safety. However, reports of serious adverse events arising from cell therapy in other poorly regulated centers have now emerged in the lay and scientific press. While progress in stem cell research for blindness has been greeted with great enthusiasm by patients, scientists, doctors and industry alike, these adverse events have raised concerns about the safety of retinal stem cell transplantation and whether patients are truly protected from undue harm. The aim of this review is to summarize and appraise the safety of human retinal stem cell transplantation in the context of its potential to be developed into an effective treatment for retinal degenerative diseases.
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