期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 40, 页码 19802-19804出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1909311116
关键词
microbiome; glucose homeostasis; microbe-host interactions; serotonin
资金
- National Health and Medical Research Council (NHMRC) Career Development Fellowship
- Canada Research Chair
- J. Bruce Duncan Endowed Chair in Metabolic Diseases
- Canadian Institutes of Health Research [201709FDN-CEBA-116200]
- Australian NHMRC [APP1088737]
The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin.
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